In addition, the activity of 12815A was markedly decreased under acidic conditions, resulting in irreversible inactivation. The only structural difference between 12815A and B is the presence of an additional chloric atom. Compound 12815A (IC 50 values about 9 μ M) showed more potent tyrosinase inhibition than compound 12815B (IC 50 values about 1086 μ M). The results obtained suggest that the active compounds are SF 2583A and B. The identification of two anti-tyrosinase compounds was performed with instrumental analysis and database search. Final HPLC analysis revealed at least two anti-tyrosinase compounds with different retention times (12815A and B). The compounds with anti-tyrosinase activity were purified by several chromatographic procedures. We examined the biological activities present in Streptomyces strains preserved at the National Institute of Technology and Evaluation Biological Resource Center, and found a metabolite of Streptomyces roseolilacinus NBRC 12815 that showed a potent anti-tyrosinase activity. NITE Biotechnology Development Center (NBDC), Department of Biotechnology, National Institute of Technology and Evaluation (NITE)ĭepartment of Chemistry, Biology and Marine Science, University of the Ryukyus Kitasato Institute for Life Sciences, Kitasato University NITE Biotechnology Development Center (NBDC), Department of Biotechnology, National Institute of Technology and Evaluation (NITE) OP Bio Factory Co., Ltd.
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